PHYSICAL AND BEHAVIOURAL HEALTH OF DOGS BELONGING TO HOMELESS PEOPLE



Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study

Abstract Background This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusional 5-fluorouracil (5-FU) in the first-line treatment of EGFR-detectable metastatic colorectal cancer.Methods The 5-FU dos

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Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala.

Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity.However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains unknown.Here we provide the first Board Game/Gently Used Games evidence that protein degradation thr

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